KIAA1033 [The Human Chemical-Genetic Interaction Map Project]

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======= KIAA1033 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WASHC4
  * **<color #00a2e8>Official Name</color>**: WASH complex subunit 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23325|23325]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q2M389|Q2M389]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIAA1033&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIAA1033|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615748|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of the WASH complex, which functions in the intracellular transport of endosomes. Mutations in this gene have been detected in individuals with autosomal recessive cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in the regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093). {ECO:0000250|UniProtKB:Q3UMB9, ECO:0000303|PubMed:21498477, ECO:0000305|PubMed:19922875, ECO:0000305|PubMed:20498093}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|WASH complex|
|BLOC-1 complex|
|endosome organization|
|endosomal transport|
|early endosome|
|endosome|
|vesicle organization|
|endomembrane system organization|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-3.02|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.58|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.1|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.92|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.9|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.89|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.73|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.71|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.7|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.7|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.7|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.71|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.77|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.8|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.86|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.88|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|2.3|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kiaa0196|KIAA0196]]|0.634|
|[[:human genes:c:ccdc53|CCDC53]]|0.577|
|[[:human genes:c:commd7|COMMD7]]|0.499|
|[[:human genes:c:ccdc22|CCDC22]]|0.49|
|[[:human genes:a:arpc4|ARPC4]]|0.447|
|[[:human genes:v:vps45|VPS45]]|0.446|
|[[:human genes:a:arpc2|ARPC2]]|0.433|
|[[:human genes:c:commd9|COMMD9]]|0.428|
|[[:human genes:c:cnot4|CNOT4]]|0.425|
|[[:human genes:c:commd2|COMMD2]]|0.422|
|[[:human genes:c:commd3|COMMD3]]|0.413|
|[[:human genes:a:actr3|ACTR3]]|0.411|
|[[:human genes:c:commd5|COMMD5]]|0.41|
|[[:human genes:v:vps29|VPS29]]|0.407|
|[[:human genes:r:rab7a|RAB7A]]|0.406|
|[[:human genes:c:commd10|COMMD10]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6109
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIAA1033 Expression in NALM6 Cells: 7.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>