KIAA1033

Entrez Summary: This gene encodes a component of the WASH complex, which functions in the intracellular transport of endosomes. Mutations in this gene have been detected in individuals with autosomal recessive cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
UniProt Summary: Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in the regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093). {ECO:0000250|UniProtKB:Q3UMB9, ECO:0000303|PubMed:21498477, ECO:0000305|PubMed:19922875, ECO:0000305|PubMed:20498093}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bafilomycin-A1 0.009μM R08 exp454	-3.02
Clomiphene 4.4μM R02 exp68	-2.58
IU1-47 25μM R04 exp182	-2.1
BH1 1μM R04 exp169	-1.92
BS-181 20μM R08 exp461	-1.9
CoCl2 18μM R07 exp346	-1.89
Adefovir 20μM R07 exp332	-1.73
Cryptotanshinone 12μM R05 exp227	-1.71
Nicotine 3000μM R08 exp510	-1.7
Brefeldin A 0.02μM R00 exp8	1.7
Cerivastatin 0.15μM R05 exp226	1.7
Menadione 5μM R06 exp292	1.71
Wortmannin 5μM R00 exp38	1.77
Nutlin-3A 1.6μM R06 exp294	1.8
Nifuroxazide 5μM R03 exp102	1.86
Fluvastatin 2.2μM R06 exp282	1.88
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	2.3
Arsenate 40μM R06 exp264	2.95

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

WASH complex
BLOC-1 complex
endosome organization
endosomal transport
early endosome
endosome
vesicle organization
endomembrane system organization
protein transport
intracellular transport
peptide transport
amide transport
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport