KIF13A [The Human Chemical-Genetic Interaction Map Project]

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======= KIF13A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF13A
  * **<color #00a2e8>Official Name</color>**: kinesin family member 13A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=63971|63971]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H1H9|Q9H1H9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF13A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF13A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605433|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3694|
|KIF1B|
|Kinesin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|plus-end-directed vesicle transport along microtubule|
|plus-end-directed organelle transport along microtubule|
|melanosome organization|
|pigment granule organization|
|vesicle cargo loading|
|Golgi to plasma membrane protein transport|
|vesicle transport along microtubule|
|cellular pigmentation|
|vesicle cytoskeletal trafficking|
|establishment of protein localization to plasma membrane|
|kinesin complex|
|endosome to lysosome transport|
|Golgi to plasma membrane transport|
|microtubule motor activity|
|organelle transport along microtubule|
|regulation of cytokinesis|
|pigmentation|
|vesicle-mediated transport to the plasma membrane|
|trans-Golgi network membrane|
|post-Golgi vesicle-mediated transport|
|lysosomal transport|
|vacuolar transport|
|transport along microtubule|
|midbody|
|regulation of cell division|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|protein localization to plasma membrane|
|vesicle localization|
|endosome membrane|
|protein localization to cell periphery|
|ATPase activity|
|microtubule binding|
|establishment of protein localization to membrane|
|microtubule-based movement|
|vesicle organization|
|microtubule|
|establishment of organelle localization|
|Golgi vesicle transport|
|protein localization to membrane|
|centrosome|
|cell division|
|organelle localization|
|microtubule-based process|
|regulation of cell cycle process|
|intracellular protein transport|
|regulation of cell cycle|
|cell cycle|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-2.09|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.82|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|1.93|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.97|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2.04|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.58|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11207
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF13A Expression in NALM6 Cells: 4.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>