KIF13A

Entrez Summary: This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

plus-end-directed vesicle transport along microtubule
plus-end-directed organelle transport along microtubule
melanosome organization
pigment granule organization
vesicle cargo loading
Golgi to plasma membrane protein transport
vesicle transport along microtubule
cellular pigmentation
vesicle cytoskeletal trafficking
establishment of protein localization to plasma membrane
kinesin complex
endosome to lysosome transport
Golgi to plasma membrane transport
microtubule motor activity
organelle transport along microtubule
regulation of cytokinesis
pigmentation
vesicle-mediated transport to the plasma membrane
trans-Golgi network membrane
post-Golgi vesicle-mediated transport
lysosomal transport
vacuolar transport
transport along microtubule
midbody
regulation of cell division
establishment of vesicle localization
cytoskeleton-dependent intracellular transport
microtubule-based transport
protein localization to plasma membrane
vesicle localization
endosome membrane
protein localization to cell periphery
ATPase activity
microtubule binding
establishment of protein localization to membrane
microtubule-based movement
vesicle organization
microtubule
establishment of organelle localization
Golgi vesicle transport