KIF15 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= KIF15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF15
  * **<color #00a2e8>Official Name</color>**: kinesin family member 15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56992|56992]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NS87|Q9NS87]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617569|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kinesin-relat 1|
|Kinesin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|plus-end kinesin complex|
|motor activity|
|kinesin complex|
|microtubule motor activity|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|spindle|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|antigen processing and presentation|
|ATPase activity|
|microtubule binding|
|microtubule-based movement|
|microtubule|
|Golgi vesicle transport|
|centrosome|
|microtubule-based process|
|mitotic cell cycle|
|cell cycle|
|ATP binding|
|movement of cell or subcellular component|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-5.67|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-5.11|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-4.43|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-3.53|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-3.31|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-3.22|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-3.16|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-3.09|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.9|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.75|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.61|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.34|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.27|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.8|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dlgap5|DLGAP5]]|0.625|
|[[:human genes:m:mapre1|MAPRE1]]|0.536|
|[[:human genes:t:tacc3|TACC3]]|0.531|
|[[:human genes:a:aspm|ASPM]]|0.456|
|[[:human genes:g:gsg2|GSG2]]|0.439|
|[[:human genes:l:lrrc8a|LRRC8A]]|0.421|
|[[:human genes:k:klf16|KLF16]]|0.412|
|[[:human genes:k:kif18a|KIF18A]]|0.403|
|[[:human genes:v:vbp1|VBP1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13163
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF15 Expression in NALM6 Cells: 6.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>