KIF15

Entrez Summary: N/A
UniProt Summary: Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Demecolcine 0.03μM R05 exp228	-5.67
Colchicine 0.009μM R05 exp215	-5.11
S-trityl-L-cysteine 0.5μM R05 exp243	-4.43
Vinblastine 0.002μM R01 exp60	-3.53
BML-284 0.09μM R08 exp460	-3.31
Vincristine 0.0005μM R04 exp190	-3.22
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-3.16
BI-6727 0.0125μM R03 exp97	-3.09
BI-2536 0.0042μM R03 exp95	-2.9
Thimerosal 0.85μM R08 exp529	-2.75
GSK461364A 0.005μM R03 exp125	-2.61
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2.34
Mdivi-1 15μM R05 exp217	-2.27
Sulforaphane 9μM R08 exp525	-1.8
Taxol 0.004μM R03 exp103	-1.72

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	3/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Kinesin-relat 1
Kinesin

plus-end kinesin complex
motor activity
kinesin complex
microtubule motor activity
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
spindle
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
antigen processing and presentation
ATPase activity
microtubule binding
microtubule-based movement
microtubule
Golgi vesicle transport
centrosome
microtubule-based process
mitotic cell cycle
cell cycle
ATP binding
movement of cell or subcellular component
vesicle-mediated transport
membrane