KIF25 [The Human Chemical-Genetic Interaction Map Project]

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======= KIF25 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF25
  * **<color #00a2e8>Official Name</color>**: kinesin family member 25
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3834|3834]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UIL4|Q9UIL4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF25&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF25|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603815|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Minus-end microtubule-dependent motor protein (By similarity). Acts as a negative regulator of centrosome separation required to prevent premature centrosome separation during interphase (PubMed:28263957). Required to maintain a centered nucleus to ensure that the spindle is stably oriented at the onset of mitosis (PubMed:28263957). May also act as a negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000250|UniProtKB:Q4R918, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:28263957}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kinesin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of mitotic centrosome separation|
|regulation of mitotic centrosome separation|
|negative regulation of centrosome cycle|
|ATP-dependent microtubule motor activity, minus-end-directed|
|nucleus localization|
|establishment of spindle orientation|
|negative regulation of mitotic nuclear division|
|establishment of spindle localization|
|negative regulation of nuclear division|
|spindle localization|
|kinesin complex|
|regulation of centrosome cycle|
|microtubule motor activity|
|negative regulation of autophagy|
|protein homotetramerization|
|mitotic sister chromatid segregation|
|establishment of cell polarity|
|negative regulation of cytoskeleton organization|
|sister chromatid segregation|
|mitotic nuclear division|
|protein tetramerization|
|regulation of mitotic nuclear division|
|regulation of microtubule cytoskeleton organization|
|regulation of nuclear division|
|establishment or maintenance of cell polarity|
|nuclear chromosome segregation|
|regulation of microtubule-based process|
|ATPase activity|
|microtubule binding|
|negative regulation of cellular catabolic process|
|microtubule-based movement|
|chromosome segregation|
|nuclear division|
|negative regulation of mitotic cell cycle|
|negative regulation of catabolic process|
|organelle fission|
|microtubule|
|negative regulation of cell cycle process|
|regulation of autophagy|
|protein homooligomerization|
|establishment of organelle localization|
|negative regulation of organelle organization|
|microtubule cytoskeleton organization|
|centrosome|
|protein complex oligomerization|
|regulation of cytoskeleton organization|
|negative regulation of cell cycle|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|regulation of cellular catabolic process|
|regulation of catabolic process|
|cell cycle process|
|chromosome organization|
|cytoskeleton organization|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|ATP binding|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|establishment of localization in cell|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.11|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.93|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.82|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-1.81|
|[[:results:exp132|Metformin 40μM R03 exp132]]|-1.77|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-1.73|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.71|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18599
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF25 Expression in NALM6 Cells: -1.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>