KIF25

Entrez Summary: N/A
UniProt Summary: Minus-end microtubule-dependent motor protein (By similarity). Acts as a negative regulator of centrosome separation required to prevent premature centrosome separation during interphase (PubMed:28263957). Required to maintain a centered nucleus to ensure that the spindle is stably oriented at the onset of mitosis (PubMed:28263957). May also act as a negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000250|UniProtKB:Q4R918, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:28263957}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Taxol 0.004μM R03 exp103	-2.11
TRAIL 5ng/ml R00 exp35	-1.93
WNT3A 44ng/ml R08 exp537	-1.82
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-1.81
Metformin 40μM R03 exp132	-1.77
Pyrazinamide 100μM R08 exp516	-1.73
Momordin-Ic 10μM R08 exp506	-1.71
Bisphenol A 100μM R06 exp269	1.72

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of mitotic centrosome separation
regulation of mitotic centrosome separation
negative regulation of centrosome cycle
ATP-dependent microtubule motor activity, minus-end-directed
nucleus localization
establishment of spindle orientation
negative regulation of mitotic nuclear division
establishment of spindle localization
negative regulation of nuclear division
spindle localization
kinesin complex
regulation of centrosome cycle
microtubule motor activity
negative regulation of autophagy
protein homotetramerization
mitotic sister chromatid segregation
establishment of cell polarity
negative regulation of cytoskeleton organization
sister chromatid segregation
mitotic nuclear division
protein tetramerization
regulation of mitotic nuclear division
regulation of microtubule cytoskeleton organization
regulation of nuclear division
establishment or maintenance of cell polarity
nuclear chromosome segregation
regulation of microtubule-based process
ATPase activity
microtubule binding
negative regulation of cellular catabolic process
microtubule-based movement
chromosome segregation
nuclear division
negative regulation of mitotic cell cycle
negative regulation of catabolic process
organelle fission
microtubule
negative regulation of cell cycle process
regulation of autophagy
protein homooligomerization