KIF2C [The Human Chemical-Genetic Interaction Map Project]

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======= KIF2C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF2C
  * **<color #00a2e8>Official Name</color>**: kinesin family member 2C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11004|11004]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99661|Q99661]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF2C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF2C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604538|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome- microtubule attachment (PubMed:23891108). {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kinesin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|establishment or maintenance of microtubule cytoskeleton polarity|
|centromeric DNA binding|
|attachment of mitotic spindle microtubules to kinetochore|
|establishment or maintenance of cytoskeleton polarity|
|microtubule plus-end binding|
|microtubule depolymerization|
|attachment of spindle microtubules to kinetochore|
|microtubule plus-end|
|protein depolymerization|
|mitotic metaphase plate congression|
|microtubule polymerization or depolymerization|
|cytoplasmic microtubule|
|kinesin complex|
|chromosome, centromeric region|
|metaphase plate congression|
|microtubule motor activity|
|establishment of chromosome localization|
|chromosome localization|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|kinetochore|
|condensed chromosome kinetochore|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|regulation of chromosome segregation|
|mitotic sister chromatid segregation|
|cellular protein complex disassembly|
|sister chromatid segregation|
|mitotic nuclear division|
|microtubule cytoskeleton|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|establishment or maintenance of cell polarity|
|antigen processing and presentation|
|nuclear chromosome segregation|
|ATPase activity|
|microtubule binding|
|protein-containing complex disassembly|
|microtubule-based movement|
|chromosome segregation|
|nuclear division|
|organelle fission|
|microtubule|
|establishment of organelle localization|
|Golgi vesicle transport|
|cellular component disassembly|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|organelle localization|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|cell cycle process|
|chromosome organization|
|cytoskeleton organization|
|cell cycle|
|ATP binding|
|movement of cell or subcellular component|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-4.17|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-3.2|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.89|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.44|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.29|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.08|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.93|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.85|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.73|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.7|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.95|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.05|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|2.1|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|2.53|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|3.29|
|[[:results:exp59|UMK57 1μM R01 exp59]]|4.44|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|5.88|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|5.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kif18b|KIF18B]]|0.762|
|[[:human genes:p:ppp2r5c|PPP2R5C]]|0.463|
|[[:human genes:k:kif4a|KIF4A]]|0.435|
|[[:human genes:c:clasp2|CLASP2]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 23/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|5/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8767
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF2C Expression in NALM6 Cells: 7.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>