KIF2C

Gene Information

Official Symbol: KIF2C
Official Name: kinesin family member 2C
Aliases and Previous Symbols: N/A
Entrez ID: 11004
UniProt: Q99661
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome- microtubule attachment (PubMed:23891108). {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Taxol 0.004μM R03 exp103	-4.17
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-3.2
Docetaxel 0.002μM R01 exp45	-2.89
Rucaparib 6.5μM R08 exp520	-2.44
Taxol 0.002μM R01 exp54	-2.29
Cabazitaxel 0.001μM R05 exp223	-2.08
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-1.93
S-trityl-L-cysteine 0.5μM R05 exp243	-1.85
Vincristine 0.0005μM R04 exp190	-1.73
Rapamycin 10μM R00 exp30	-1.7
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	1.95
BML-284 0.09μM R08 exp460	2.05
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	2.1
2-Methoxyestradiol 0.55μM R07 exp310	2.53
HMS-I1 1μM R01 exp46	3.29
UMK57 1μM R01 exp59	4.44
Mdivi-1 15μM R05 exp217	5.88
UM131593 0.2μM R03 exp106	5.95

Global Fraction of Cell Lines Where Essential: 23/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	3/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	5/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	3/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8767
Expression level (log2 read counts): 7.14

Expression Distribution

Gene	Correlation
KIF18B	0.762
PPP2R5C	0.463
KIF4A	0.435
CLASP2	0.405

establishment or maintenance of microtubule cytoskeleton polarity
centromeric DNA binding
attachment of mitotic spindle microtubules to kinetochore
establishment or maintenance of cytoskeleton polarity
microtubule plus-end binding
microtubule depolymerization
attachment of spindle microtubules to kinetochore
microtubule plus-end
protein depolymerization
mitotic metaphase plate congression
microtubule polymerization or depolymerization
cytoplasmic microtubule
kinesin complex
chromosome, centromeric region
metaphase plate congression
microtubule motor activity
establishment of chromosome localization
chromosome localization
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
kinetochore
condensed chromosome kinetochore
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
regulation of chromosome segregation
mitotic sister chromatid segregation
cellular protein complex disassembly
sister chromatid segregation
mitotic nuclear division
microtubule cytoskeleton
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
establishment or maintenance of cell polarity
antigen processing and presentation
nuclear chromosome segregation
ATPase activity
microtubule binding
protein-containing complex disassembly
microtubule-based movement