KIF3B [The Human Chemical-Genetic Interaction Map Project]

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======= KIF3B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF3B
  * **<color #00a2e8>Official Name</color>**: kinesin family member 3B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9371|9371]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15066|O15066]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF3B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF3B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603754|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kinesin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|kinesin II complex|
|plus-end kinesin complex|
|intraciliary transport particle B binding|
|mitotic centrosome separation|
|plus-end-directed vesicle transport along microtubule|
|plus-end-directed organelle transport along microtubule|
|centrosome separation|
|ATP-dependent microtubule motor activity, plus-end-directed|
|Rho GTPase binding|
|mitotic spindle assembly|
|spindle microtubule|
|positive regulation of cytokinesis|
|intraciliary transport involved in cilium assembly|
|vesicle transport along microtubule|
|anterograde axonal transport|
|ciliary tip|
|vesicle cytoskeletal trafficking|
|intraciliary transport|
|kinesin complex|
|axonal transport|
|axon cytoplasm|
|axo-dendritic transport|
|microtubule-based protein transport|
|protein transport along microtubule|
|microtubule motor activity|
|mitotic spindle organization|
|organelle transport along microtubule|
|centrosome cycle|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|positive regulation of cell division|
|regulation of cytokinesis|
|microtubule organizing center organization|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|spindle assembly|
|microtubule cytoskeleton organization involved in mitosis|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|mitotic nuclear division|
|microtubule cytoskeleton|
|spindle organization|
|transport along microtubule|
|midbody|
|regulation of cell division|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|antigen processing and presentation of exogenous peptide antigen|
|microtubule-based transport|
|antigen processing and presentation of exogenous antigen|
|vesicle localization|
|antigen processing and presentation of peptide antigen|
|cilium|
|antigen processing and presentation|
|ATPase activity|
|microtubule binding|
|protein-containing complex localization|
|microtubule-based movement|
|nuclear division|
|positive regulation of cell cycle process|
|organelle fission|
|microtubule|
|cilium assembly|
|establishment of organelle localization|
|cilium organization|
|Golgi vesicle transport|
|positive regulation of cell cycle|
|pattern specification process|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|microtubule cytoskeleton organization|
|centrosome|
|organelle localization|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|regulation of cell cycle process|
|organelle assembly|
|intracellular protein transport|
|cell cycle process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|cell cycle|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp518|RK-33 8μM R08 exp518]]|-1.72|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.88|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.96|
|[[:results:exp331|A-769662 20μM R07 exp331]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.46|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2869
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF3B Expression in NALM6 Cells: 5.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>