KIF5B
Gene Information
- Official Symbol: KIF5B
- Official Name: kinesin family member 5B
- Aliases and Previous Symbols: N/A
- Entrez ID: 3799
- UniProt: P33176
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). {ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726}.
Pfam Domains GO Terms
Pfam Domains
| Kinesin |
GO Terms
| positive regulation of voltage-gated sodium channel activity |
| microtubule lateral binding |
| regulation of voltage-gated sodium channel activity |
| anterograde neuronal dense core vesicle transport |
| stress granule disassembly |
| retrograde neuronal dense core vesicle transport |
| dense core granule cytoskeletal transport |
| dense core granule transport |
| dense core granule localization |
| plus-end-directed vesicle transport along microtubule |
| JUN kinase binding |
| plus-end-directed organelle transport along microtubule |
| protein localization to presynapse |
| anterograde axonal protein transport |
| cytoplasm organization |
| secretory granule localization |
| ciliary rootlet |
| positive regulation of vesicle fusion |
| positive regulation of synaptic transmission, GABAergic |
| axo-dendritic protein transport |
| ribonucleoprotein complex disassembly |
| positive regulation of sodium ion transmembrane transporter activity |
| retrograde axonal transport |
| positive regulation of sodium ion transmembrane transport |
| axonal growth cone |
| centrosome localization |
| microtubule organizing center localization |
| regulation of vesicle fusion |
| regulation of synaptic transmission, GABAergic |
| positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| positive regulation of sodium ion transport |
| anterograde axonal transport |
| vesicle transport along microtubule |
| positive regulation of potassium ion transport |
| vesicle cytoskeletal trafficking |
| kinesin complex |
| regulation of sodium ion transmembrane transporter activity |
| positive regulation of protein localization to plasma membrane |
| axonal transport |
| axon cytoplasm |
| regulation of insulin secretion involved in cellular response to glucose stimulus |
| phagocytic vesicle |
| positive regulation of protein localization to cell periphery |
| regulation of sodium ion transmembrane transport |
| protein localization to synapse |
| organelle disassembly |
| axo-dendritic transport |
| microtubule motor activity |
| protein transport along microtubule |
| microtubule-based protein transport |
| positive regulation of cation channel activity |
| positive regulation of insulin secretion |
| organelle transport along microtubule |
| hippocampus development |
| regulation of sodium ion transport |
| regulation of protein localization to plasma membrane |
| regulation of potassium ion transport |
| positive regulation of peptide hormone secretion |
| positive regulation of ion transmembrane transporter activity |
| limbic system development |
| positive regulation of transporter activity |
| regulation of protein localization to cell periphery |
| positive regulation of protein localization to membrane |
| positive regulation of hormone secretion |
| vesicle |
| positive regulation of cation transmembrane transport |
| cytosolic transport |
| positive regulation of synaptic transmission |
| positive regulation of intracellular protein transport |
| positive regulation of ion transmembrane transport |
| transport along microtubule |
| microtubule organizing center |
| cellular response to interferon-gamma |
| regulation of cation channel activity |
| pallium development |
| establishment of vesicle localization |
| cytoskeleton-dependent intracellular transport |
| regulation of insulin secretion |
| response to interferon-gamma |
| microtubule-based transport |
| vesicle localization |
| regulation of protein localization to membrane |
| positive regulation of transmembrane transport |
| positive regulation of intracellular transport |
| regulation of peptide hormone secretion |
| regulation of intracellular protein transport |
| ATPase activity |
| microtubule binding |
| protein-containing complex disassembly |
| ribonucleoprotein complex subunit organization |
| regulation of ion transmembrane transporter activity |
| telencephalon development |
| regulation of transmembrane transporter activity |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| microtubule-based movement |
| positive regulation of ion transport |
| regulation of transporter activity |
| positive regulation of peptide secretion |
| cadherin binding |
| microtubule |
| positive regulation of cellular protein localization |
| regulation of cation transmembrane transport |
| regulation of intracellular transport |
| establishment of organelle localization |
| regulation of metal ion transport |
| forebrain development |
| cellular component disassembly |
| positive regulation of secretion by cell |
| positive regulation of protein transport |
| regulation of membrane potential |
| positive regulation of secretion |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of ion transmembrane transport |
| regulation of peptide secretion |
| regulation of hormone levels |
| regulation of cellular protein localization |
| regulation of vesicle-mediated transport |
| regulation of transmembrane transport |
| organelle localization |
| positive regulation of organelle organization |
| microtubule-based process |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| regulation of protein transport |
| regulation of peptide transport |
| brain development |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| innate immune response |
| head development |
| regulation of secretion |
| regulation of cellular localization |
| defense response to other organism |
| central nervous system development |
| positive regulation of transport |
| intracellular protein transport |
| cellular response to cytokine stimulus |
| regulation of protein localization |
| identical protein binding |
| response to cytokine |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| ATP binding |
| protein transport |
| intracellular transport |
| peptide transport |
| movement of cell or subcellular component |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| positive regulation of molecular function |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3590
- Expression level (log2 read counts): 8.05
Expression Distribution
KIF5B Expression in NALM6 Cells: 8.05
