KIRREL

Gene Information

Official Symbol: KIRREL1
Official Name: kirre like nephrin family adhesion molecule 1
Aliases and Previous Symbols: N/A
Entrez ID: 55243
UniProt: Q96J84
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9978
Expression level (log2 read counts): -1.33

Expression Distribution

C2-set 2
I-set
ig

cell projection membrane
myosin binding
dendritic shaft
excretion
positive regulation of actin filament polymerization
positive regulation of protein polymerization
regulation of actin filament polymerization
cell-cell junction
regulation of actin polymerization or depolymerization
regulation of actin filament length
positive regulation of supramolecular fiber organization
positive regulation of cytoskeleton organization
regulation of protein polymerization
membrane raft
positive regulation of protein complex assembly
regulation of actin filament organization
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
regulation of cellular component size
regulation of actin filament-based process
negative regulation of protein phosphorylation
negative regulation of phosphorylation
regulation of protein complex assembly
cell-cell adhesion
regulation of anatomical structure size
positive regulation of cellular component biogenesis
regulation of cytoskeleton organization
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
positive regulation of organelle organization
perinuclear region of cytoplasm
cell adhesion
biological adhesion
regulation of cellular component biogenesis
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
positive regulation of cellular component organization
regulation of organelle organization
regulation of protein phosphorylation