KLF15 [The Human Chemical-Genetic Interaction Map Project]

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======= KLF15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KLF15
  * **<color #00a2e8>Official Name</color>**: Kruppel like factor 15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=28999|28999]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UIH9|Q9UIH9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KLF15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KLF15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606465|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation. {ECO:0000250, ECO:0000269|PubMed:18586263, ECO:0000269|PubMed:20375365, ECO:0000269|PubMed:20566642, ECO:0000269|PubMed:23999430}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C2H2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cardiac muscle adaptation|
|muscle hypertrophy in response to stress|
|cardiac muscle hypertrophy in response to stress|
|glomerular visceral epithelial cell differentiation|
|renal filtration cell differentiation|
|glomerular epithelial cell differentiation|
|negative regulation of peptidyl-lysine acetylation|
|glomerular epithelium development|
|negative regulation of protein acetylation|
|striated muscle adaptation|
|cardiac muscle hypertrophy|
|epithelial cell differentiation involved in kidney development|
|striated muscle hypertrophy|
|muscle hypertrophy|
|muscle adaptation|
|positive regulation of glucose import|
|cell differentiation involved in kidney development|
|positive regulation of glucose transmembrane transport|
|glomerulus development|
|regulation of glucose import|
|regulation of peptidyl-lysine acetylation|
|regulation of protein acetylation|
|regulation of glucose transmembrane transport|
|cellular glucose homeostasis|
|nephron epithelium development|
|nephron development|
|kidney epithelium development|
|glial cell differentiation|
|glucose homeostasis|
|carbohydrate homeostasis|
|positive regulation of transmembrane transport|
|gliogenesis|
|transcription regulatory region DNA binding|
|response to insulin|
|kidney development|
|renal system development|
|muscle system process|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|urogenital system development|
|cellular response to peptide|
|response to peptide hormone|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|response to peptide|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|regulation of transmembrane transport|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|epithelial cell differentiation|
|cellular chemical homeostasis|
|cellular homeostasis|
|response to hormone|
|positive regulation of transport|
|response to organonitrogen compound|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|epithelium development|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10514
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KLF15 Expression in NALM6 Cells: 4.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>