KLF15

Entrez Summary: N/A
UniProt Summary: Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation. {ECO:0000250, ECO:0000269|PubMed:18586263, ECO:0000269|PubMed:20375365, ECO:0000269|PubMed:20566642, ECO:0000269|PubMed:23999430}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cardiac muscle adaptation
muscle hypertrophy in response to stress
cardiac muscle hypertrophy in response to stress
glomerular visceral epithelial cell differentiation
renal filtration cell differentiation
glomerular epithelial cell differentiation
negative regulation of peptidyl-lysine acetylation
glomerular epithelium development
negative regulation of protein acetylation
striated muscle adaptation
cardiac muscle hypertrophy
epithelial cell differentiation involved in kidney development
striated muscle hypertrophy
muscle hypertrophy
muscle adaptation
positive regulation of glucose import
cell differentiation involved in kidney development
positive regulation of glucose transmembrane transport
glomerulus development
regulation of glucose import
regulation of peptidyl-lysine acetylation
regulation of protein acetylation
regulation of glucose transmembrane transport
cellular glucose homeostasis
nephron epithelium development
nephron development
kidney epithelium development
glial cell differentiation
glucose homeostasis
carbohydrate homeostasis
positive regulation of transmembrane transport
gliogenesis
transcription regulatory region DNA binding
response to insulin
kidney development
renal system development
muscle system process
RNA polymerase II regulatory region sequence-specific DNA binding
urogenital system development
cellular response to peptide