KLF2 [The Human Chemical-Genetic Interaction Map Project]

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======= KLF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KLF2
  * **<color #00a2e8>Official Name</color>**: Kruppel like factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10365|10365]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5W3|Q9Y5W3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KLF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KLF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602016|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. {ECO:0000269|PubMed:21063504}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C2H2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|stress response to acid chemical|
|cellular stress response to acid chemical|
|cellular response to cycloheximide|
|response to cycloheximide|
|type I pneumocyte differentiation|
|cellular response to laminar fluid shear stress|
|response to fungicide|
|response to laminar fluid shear stress|
|erythrocyte maturation|
|cellular response to fluid shear stress|
|lung epithelial cell differentiation|
|lung cell differentiation|
|negative regulation of sprouting angiogenesis|
|lung epithelium development|
|positive regulation of transcription from RNA polymerase II promoter in response to stress|
|erythrocyte development|
|response to fluid shear stress|
|positive regulation of nitric oxide biosynthetic process|
|positive regulation of nitric oxide metabolic process|
|negative regulation of interleukin-6 production|
|positive regulation of reactive oxygen species biosynthetic process|
|regulation of nitric oxide biosynthetic process|
|myeloid cell development|
|regulation of sprouting angiogenesis|
|cellular response to hydrogen peroxide|
|erythrocyte differentiation|
|multicellular organism growth|
|cellular response to alcohol|
|regulation of reactive oxygen species biosynthetic process|
|erythrocyte homeostasis|
|cellular response to ketone|
|positive regulation of reactive oxygen species metabolic process|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|myeloid cell homeostasis|
|negative regulation of vasculature development|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|regulation of DNA-templated transcription in response to stress|
|cellular response to reactive oxygen species|
|anatomical structure maturation|
|regulation of interleukin-6 production|
|cell maturation|
|lung development|
|respiratory tube development|
|cellular response to interleukin-1|
|regulation of reactive oxygen species metabolic process|
|response to ketone|
|response to reactive oxygen species|
|respiratory system development|
|response to interleukin-1|
|homeostasis of number of cells|
|cellular response to acid chemical|
|cellular response to toxic substance|
|myeloid cell differentiation|
|response to alcohol|
|regulation of gene expression, epigenetic|
|nuclear chromatin|
|developmental maturation|
|cellular response to oxidative stress|
|cellular response to tumor necrosis factor|
|response to tumor necrosis factor|
|negative regulation of cytokine production|
|regulation of angiogenesis|
|response to antibiotic|
|regulation of vasculature development|
|cellular response to peptide|
|response to acid chemical|
|regulation of neurotransmitter levels|
|in utero embryonic development|
|response to oxidative stress|
|developmental growth|
|growth|
|cellular response to drug|
|response to peptide|
|response to toxic substance|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|hemopoiesis|
|cellular response to organonitrogen compound|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|cellular response to nitrogen compound|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|regulation of cytokine production|
|cell morphogenesis|
|cellular component morphogenesis|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|response to organic cyclic compound|
|negative regulation of developmental process|
|embryo development|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|response to drug|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|response to cytokine|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.98|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.81|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.78|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.9|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10785
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KLF2 Expression in NALM6 Cells: 0.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>