KLF2
Gene Information
- Official Symbol: KLF2
- Official Name: Kruppel like factor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 10365
- UniProt: Q9Y5W3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. {ECO:0000269|PubMed:21063504}.
Pfam Domains GO Terms
Pfam Domains
| zf-C2H2 |
GO Terms
| stress response to acid chemical |
| cellular stress response to acid chemical |
| cellular response to cycloheximide |
| response to cycloheximide |
| type I pneumocyte differentiation |
| cellular response to laminar fluid shear stress |
| response to fungicide |
| response to laminar fluid shear stress |
| erythrocyte maturation |
| cellular response to fluid shear stress |
| lung epithelial cell differentiation |
| lung cell differentiation |
| negative regulation of sprouting angiogenesis |
| lung epithelium development |
| positive regulation of transcription from RNA polymerase II promoter in response to stress |
| erythrocyte development |
| response to fluid shear stress |
| positive regulation of nitric oxide biosynthetic process |
| positive regulation of nitric oxide metabolic process |
| negative regulation of interleukin-6 production |
| positive regulation of reactive oxygen species biosynthetic process |
| regulation of nitric oxide biosynthetic process |
| myeloid cell development |
| regulation of sprouting angiogenesis |
| cellular response to hydrogen peroxide |
| erythrocyte differentiation |
| multicellular organism growth |
| cellular response to alcohol |
| regulation of reactive oxygen species biosynthetic process |
| erythrocyte homeostasis |
| cellular response to ketone |
| positive regulation of reactive oxygen species metabolic process |
| negative regulation of angiogenesis |
| negative regulation of blood vessel morphogenesis |
| myeloid cell homeostasis |
| negative regulation of vasculature development |
| cellular response to antibiotic |
| response to hydrogen peroxide |
| regulation of transcription from RNA polymerase II promoter in response to stress |
| regulation of DNA-templated transcription in response to stress |
| cellular response to reactive oxygen species |
| anatomical structure maturation |
| regulation of interleukin-6 production |
| cell maturation |
| lung development |
| respiratory tube development |
| cellular response to interleukin-1 |
| regulation of reactive oxygen species metabolic process |
| response to ketone |
| response to reactive oxygen species |
| respiratory system development |
| response to interleukin-1 |
| homeostasis of number of cells |
| cellular response to acid chemical |
| cellular response to toxic substance |
| myeloid cell differentiation |
| response to alcohol |
| regulation of gene expression, epigenetic |
| nuclear chromatin |
| developmental maturation |
| cellular response to oxidative stress |
| cellular response to tumor necrosis factor |
| response to tumor necrosis factor |
| negative regulation of cytokine production |
| regulation of angiogenesis |
| response to antibiotic |
| regulation of vasculature development |
| cellular response to peptide |
| response to acid chemical |
| regulation of neurotransmitter levels |
| in utero embryonic development |
| response to oxidative stress |
| developmental growth |
| growth |
| cellular response to drug |
| response to peptide |
| response to toxic substance |
| response to inorganic substance |
| cellular response to organic cyclic compound |
| hemopoiesis |
| cellular response to organonitrogen compound |
| hematopoietic or lymphoid organ development |
| chordate embryonic development |
| immune system development |
| embryo development ending in birth or egg hatching |
| cellular response to nitrogen compound |
| DNA-binding transcription factor activity |
| epithelial cell differentiation |
| regulation of cytokine production |
| cell morphogenesis |
| cellular component morphogenesis |
| tube development |
| negative regulation of transcription by RNA polymerase II |
| response to organic cyclic compound |
| negative regulation of developmental process |
| embryo development |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| response to drug |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| response to nitrogen compound |
| response to cytokine |
| epithelium development |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10785
- Expression level (log2 read counts): 0.08
Expression Distribution
KLF2 Expression in NALM6 Cells: 0.08
