KLF7

Gene Information

Official Symbol: KLF7
Official Name: Kruppel like factor 7
Aliases and Previous Symbols: N/A
Entrez ID: 8609
UniProt: O75840
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
UniProt Summary: Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15233
Expression level (log2 read counts): 4.31

Expression Distribution

negative regulation of adipose tissue development
negative regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of adipose tissue development
negative regulation of insulin secretion
negative regulation of peptide hormone secretion
regulation of insulin secretion involved in cellular response to glucose stimulus
dendrite morphogenesis
regulation of epidermal cell differentiation
negative regulation of hormone secretion
regulation of epidermis development
dendrite development
negative regulation of protein secretion
negative regulation of peptide secretion
regulation of epithelial cell differentiation
regulation of insulin secretion
negative regulation of protein transport
glucose homeostasis
carbohydrate homeostasis
negative regulation of establishment of protein localization
negative regulation of secretion by cell
regulation of peptide hormone secretion
negative regulation of secretion
axon guidance
neuron projection guidance
regulation of hormone secretion
transcription coactivator activity
axonogenesis
axon development
cell morphogenesis involved in neuron differentiation
DNA-binding transcription activator activity, RNA polymerase II-specific
regulation of protein secretion
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
negative regulation of transport
cell projection morphogenesis
regulation of peptide secretion
RNA polymerase II proximal promoter sequence-specific DNA binding
cell part morphogenesis
regulation of hormone levels
chemotaxis