KLHDC8B
Gene Information
- Official Symbol: KLHDC8B
- Official Name: kelch domain containing 8B
- Aliases and Previous Symbols: N/A
- Entrez ID: 200942
- UniProt: Q8IXV7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma. [provided by RefSeq, Sep 2010].
- UniProt Summary: Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis (PubMed:20107318). Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells (PubMed:22988245, PubMed:23713010). {ECO:0000269|PubMed:20107318, ECO:0000269|PubMed:22988245, ECO:0000269|PubMed:23713010}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8814
- Expression level (log2 read counts): -1.89
KLHDC8B Expression in NALM6 Cells: -1.89
