KLHL22

Entrez Summary: N/A
UniProt Summary: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation. {ECO:0000269|PubMed:19995937, ECO:0000269|PubMed:23455478}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

polar microtubule
cellular response to leucine
response to leucine
positive regulation of TORC1 signaling
spindle checkpoint
mitotic spindle assembly checkpoint
spindle assembly checkpoint
mitotic spindle checkpoint
negative regulation of mitotic metaphase/anaphase transition
negative regulation of metaphase/anaphase transition of cell cycle
negative regulation of mitotic sister chromatid separation
negative regulation of chromosome separation
14-3-3 protein binding
negative regulation of mitotic sister chromatid segregation
negative regulation of sister chromatid segregation
negative regulation of chromosome segregation
Cul3-RING ubiquitin ligase complex
regulation of TORC1 signaling
positive regulation of TOR signaling
negative regulation of mitotic nuclear division
negative regulation of nuclear division
regulation of mitotic metaphase/anaphase transition
regulation of metaphase/anaphase transition of cell cycle
regulation of mitotic sister chromatid separation
protein monoubiquitination
regulation of chromosome separation
regulation of mitotic sister chromatid segregation
cellular response to amino acid stimulus
mitotic spindle
regulation of sister chromatid segregation
negative regulation of autophagy
regulation of TOR signaling
regulation of chromosome segregation
mitotic sister chromatid segregation
response to amino acid
negative regulation of chromosome organization
sister chromatid segregation
mitotic nuclear division
mitotic cell cycle checkpoint
positive regulation of cell growth