KLHL24

Entrez Summary: N/A
UniProt Summary: Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (PubMed:27889062). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation (PubMed:27798626). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). {ECO:0000250|UniProtKB:Q56A24, ECO:0000269|PubMed:27798626, ECO:0000269|PubMed:27889062}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of kainate selective glutamate receptor activity
intermediate filament organization
desmosome
Cul3-RING ubiquitin ligase complex
intermediate filament cytoskeleton organization
intermediate filament-based process
regulation of sodium ion transmembrane transporter activity
regulation of potassium ion transmembrane transporter activity
regulation of sodium ion transmembrane transport
adherens junction
regulation of glutamate receptor signaling pathway
protein autoubiquitination
regulation of neurotransmitter receptor activity
regulation of potassium ion transmembrane transport
regulation of sodium ion transport
regulation of potassium ion transport
perikaryon
regulation of cation channel activity
regulation of signaling receptor activity
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
regulation of transporter activity
axon
regulation of cation transmembrane transport
regulation of metal ion transport
supramolecular fiber organization
regulation of ion transmembrane transport
regulation of transmembrane transport
protein ubiquitination
regulation of ion transport
protein modification by small protein conjugation
protein modification by small protein conjugation or removal
cytoskeleton organization
regulation of transport