KLHL6

• Official Symbol: KLHL6
• Official Name: kelch like family member 6
• Aliases and Previous Symbols: N/A
• Entrez ID: 89857
• UniProt: Q8WZ60
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes a member of the kelch-like (KLHL) family of proteins, which is involved in B-lymphocyte antigen receptor signaling and germinal-center B-cell maturation. The encoded protein contains an N-terminal broad-complex, tramtrack and bric a brac (BTB) domain that facilitates protein binding and dimerization, a BTB and C-terminal kelch (BACK) domain, and six C-terminal kelch repeat domains. Naturally occurring mutations in this gene are associated with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017].
• UniProt Summary: Involved in B-lymphocyte antigen receptor signaling and germinal center formation. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 12675
• Expression level (log2 read counts): 6.42

Expression Distribution

×

KLHL6 Expression in NALM6 Cells: 6.42