KLK14

Entrez Summary: N/A
UniProt Summary: Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis. {ECO:0000269|PubMed:15654974, ECO:0000269|PubMed:16885167, ECO:0000269|PubMed:17158887, ECO:0000269|PubMed:17625593, ECO:0000269|PubMed:18056261, ECO:0000269|PubMed:18482984}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

seminal clot liquefaction
insemination
copulation
positive regulation of G protein-coupled receptor signaling pathway
epidermis morphogenesis
mating
negative regulation of G protein-coupled receptor signaling pathway
secretory granule
cornification
regulation of G protein-coupled receptor signaling pathway
serine-type endopeptidase activity
fertilization
multi-multicellular organism process
keratinization
keratinocyte differentiation
epidermal cell differentiation
skin development
epidermis development
morphogenesis of an epithelium
tissue morphogenesis
epithelial cell differentiation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
programmed cell death
cell death
epithelium development
negative regulation of signal transduction
proteolysis
negative regulation of cell communication
negative regulation of signaling
reproductive process
reproduction
extracellular space
negative regulation of response to stimulus
positive regulation of signal transduction
tissue development
positive regulation of cell communication
positive regulation of signaling