KLK5 [The Human Chemical-Genetic Interaction Map Project]

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======= KLK5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KLK5
  * **<color #00a2e8>Official Name</color>**: kallikrein related peptidase 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25818|25818]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y337|Q9Y337]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KLK5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KLK5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605643|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in desquamation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Trypsin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of antimicrobial peptide production|
|positive regulation of antibacterial peptide production|
|regulation of antibacterial peptide production|
|epidermal lamellar body|
|positive regulation of antimicrobial humoral response|
|regulation of antimicrobial peptide production|
|regulation of antimicrobial humoral response|
|positive regulation of defense response to bacterium|
|positive regulation of humoral immune response|
|regulation of defense response to bacterium|
|amelogenesis|
|positive regulation of G protein-coupled receptor signaling pathway|
|serine-type peptidase activity|
|extracellular matrix disassembly|
|peptidase activity|
|odontogenesis of dentin-containing tooth|
|secretory granule|
|positive regulation of production of molecular mediator of immune response|
|cornification|
|odontogenesis|
|regulation of humoral immune response|
|regulation of production of molecular mediator of immune response|
|regulation of G protein-coupled receptor signaling pathway|
|serine-type endopeptidase activity|
|positive regulation of immune effector process|
|keratinization|
|keratinocyte differentiation|
|epidermal cell differentiation|
|extracellular matrix organization|
|positive regulation of response to biotic stimulus|
|skin development|
|extracellular structure organization|
|cellular component disassembly|
|epidermis development|
|regulation of immune effector process|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|positive regulation of response to external stimulus|
|epithelial cell differentiation|
|regulation of defense response|
|regulation of multi-organism process|
|positive regulation of immune response|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|programmed cell death|
|cell death|
|regulation of response to external stimulus|
|epithelium development|
|regulation of immune response|
|positive regulation of immune system process|
|proteolysis|
|regulation of response to stress|
|extracellular space|
|positive regulation of signal transduction|
|regulation of immune system process|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.96|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11085
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KLK5 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>