KLK5

Gene Information

Official Symbol: KLK5
Official Name: kallikrein related peptidase 5
Aliases and Previous Symbols: N/A
Entrez ID: 25818
UniProt: Q9Y337
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May be involved in desquamation.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11085
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
ONC212 0.15μM R08 exp513	-1.96
Ethambutol 25μM R08 exp481	-1.71

positive regulation of antimicrobial peptide production
positive regulation of antibacterial peptide production
regulation of antibacterial peptide production
epidermal lamellar body
positive regulation of antimicrobial humoral response
regulation of antimicrobial peptide production
regulation of antimicrobial humoral response
positive regulation of defense response to bacterium
positive regulation of humoral immune response
regulation of defense response to bacterium
amelogenesis
positive regulation of G protein-coupled receptor signaling pathway
serine-type peptidase activity
extracellular matrix disassembly
peptidase activity
odontogenesis of dentin-containing tooth
secretory granule
positive regulation of production of molecular mediator of immune response
cornification
odontogenesis
regulation of humoral immune response
regulation of production of molecular mediator of immune response
regulation of G protein-coupled receptor signaling pathway
serine-type endopeptidase activity
positive regulation of immune effector process
keratinization
keratinocyte differentiation
epidermal cell differentiation
extracellular matrix organization
positive regulation of response to biotic stimulus
skin development
extracellular structure organization
cellular component disassembly
epidermis development
regulation of immune effector process
positive regulation of defense response
positive regulation of multi-organism process
regulation of response to biotic stimulus
positive regulation of response to external stimulus
epithelial cell differentiation