KLK7

Gene Information

Official Symbol: KLK7
Official Name: kallikrein related peptidase 7
Aliases and Previous Symbols: N/A
Entrez ID: 5650
UniProt: P49862
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6- Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|- Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. {ECO:0000269|PubMed:23370777}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7885
Expression level (log2 read counts): 0.75

Expression Distribution

positive regulation of antimicrobial peptide production
positive regulation of antibacterial peptide production
regulation of antibacterial peptide production
epidermal lamellar body
positive regulation of antimicrobial humoral response
regulation of antimicrobial peptide production
regulation of antimicrobial humoral response
positive regulation of defense response to bacterium
positive regulation of humoral immune response
regulation of defense response to bacterium
serine-type peptidase activity
extracellular matrix disassembly
peptidase activity
secretory granule
positive regulation of production of molecular mediator of immune response
regulation of humoral immune response
regulation of production of molecular mediator of immune response
serine-type endopeptidase activity
positive regulation of immune effector process
extracellular matrix organization
positive regulation of response to biotic stimulus
extracellular structure organization
cellular component disassembly
epidermis development
regulation of immune effector process
positive regulation of defense response
positive regulation of multi-organism process
regulation of response to biotic stimulus
positive regulation of response to external stimulus
regulation of defense response
regulation of multi-organism process
positive regulation of immune response
regulation of response to external stimulus
regulation of immune response
positive regulation of immune system process
proteolysis
regulation of response to stress
extracellular space
regulation of immune system process
tissue development