KNDC1 [The Human Chemical-Genetic Interaction Map Project]

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======= KNDC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KNDC1
  * **<color #00a2e8>Official Name</color>**: kinase non-catalytic C-lobe domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=85442|85442]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q76NI1|Q76NI1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KNDC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KNDC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616237|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies. [provided by RefSeq, Dec 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (PubMed:24788352). {ECO:0000250|UniProtKB:Q0KK55, ECO:0000269|PubMed:24788352}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RasGEF N|
|RasGEF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cerebellar granular layer formation|
|cerebellar granule cell differentiation|
|cerebellar granular layer morphogenesis|
|guanyl-nucleotide exchange factor complex|
|cerebellar granular layer development|
|Ras guanyl-nucleotide exchange factor activity|
|cell differentiation in hindbrain|
|cerebellar cortex formation|
|cerebellar cortex morphogenesis|
|cerebellum morphogenesis|
|hindbrain morphogenesis|
|cerebellar cortex development|
|regulation of dendrite morphogenesis|
|cerebellum development|
|metencephalon development|
|perikaryon|
|regulation of dendrite development|
|hindbrain development|
|central nervous system neuron differentiation|
|regulation of cell morphogenesis involved in differentiation|
|small GTPase mediated signal transduction|
|neuronal cell body|
|dendrite|
|cellular component|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|brain development|
|molecular function|
|head development|
|regulation of neurogenesis|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|central nervous system development|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.496|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4248
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KNDC1 Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>