KNDC1

Entrez Summary: The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies. [provided by RefSeq, Dec 2016].
UniProt Summary: RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (PubMed:24788352). {ECO:0000250|UniProtKB:Q0KK55, ECO:0000269|PubMed:24788352}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RasGEF N
RasGEF

cerebellar granular layer formation
cerebellar granule cell differentiation
cerebellar granular layer morphogenesis
guanyl-nucleotide exchange factor complex
cerebellar granular layer development
Ras guanyl-nucleotide exchange factor activity
cell differentiation in hindbrain
cerebellar cortex formation
cerebellar cortex morphogenesis
cerebellum morphogenesis
hindbrain morphogenesis
cerebellar cortex development
regulation of dendrite morphogenesis
cerebellum development
metencephalon development
perikaryon
regulation of dendrite development
hindbrain development
central nervous system neuron differentiation
regulation of cell morphogenesis involved in differentiation
small GTPase mediated signal transduction
neuronal cell body
dendrite
cellular component
regulation of cell morphogenesis
regulation of neuron projection development
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
brain development
molecular function
head development
regulation of neurogenesis
anatomical structure formation involved in morphogenesis
regulation of nervous system development
regulation of cell development
central nervous system development
neuron differentiation
positive regulation of protein phosphorylation
positive regulation of phosphorylation