KRT1

Entrez Summary: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008].
UniProt Summary: May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK. {ECO:0000269|PubMed:17956333, ECO:0000269|PubMed:21544310}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

complement activation, lectin pathway
structural constituent of epidermis
fibrinolysis
establishment of skin barrier
regulation of water loss via skin
protein heterotetramerization
negative regulation of blood coagulation
negative regulation of hemostasis
negative regulation of coagulation
peptide cross-linking
cornified envelope
multicellular organismal water homeostasis
negative regulation of wound healing
water homeostasis
retina homeostasis
regulation of blood coagulation
regulation of hemostasis
regulation of coagulation
negative regulation of response to wounding
keratin filament
protein heterooligomerization
cornification
ficolin-1-rich granule lumen
negative regulation of inflammatory response
regulation of wound healing
blood microparticle
protein tetramerization
regulation of response to wounding
carbohydrate binding
complement activation
tissue homeostasis
signaling receptor activity
negative regulation of defense response
keratinization
keratinocyte differentiation
regulation of angiogenesis
epidermal cell differentiation
regulation of vasculature development
multicellular organismal homeostasis
regulation of inflammatory response