KRT19

Entrez Summary: The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

terminal web
dystrophin-associated glycoprotein complex
apicolateral plasma membrane
costamere
cell differentiation involved in embryonic placenta development
cell periphery
sarcomere organization
structural constituent of muscle
myofibril assembly
response to estrogen
embryonic placenta development
sarcolemma
structural constituent of cytoskeleton
cellular component assembly involved in morphogenesis
cornification
actomyosin structure organization
intermediate filament
Notch signaling pathway
Z disc
striated muscle cell development
muscle cell development
placenta development
striated muscle cell differentiation
keratinization
muscle cell differentiation
protein-containing complex binding
keratinocyte differentiation
epidermal cell differentiation
in utero embryonic development
skin development
epidermis development
reproductive structure development
reproductive system development
embryonic organ development
supramolecular fiber organization
muscle structure development
actin cytoskeleton organization
actin filament-based process
chordate embryonic development
embryo development ending in birth or egg hatching