KRT8

Entrez Summary: This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 11/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	2/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	1/5

Expression Distribution

response to hydrostatic pressure
hepatocyte apoptotic process
response to water
dystrophin-associated glycoprotein complex
apicolateral plasma membrane
costamere
cell differentiation involved in embryonic placenta development
epithelial cell apoptotic process
sarcomere organization
intermediate filament cytoskeleton
scaffold protein binding
myofibril assembly
embryonic placenta development
extrinsic apoptotic signaling pathway
keratin filament
sarcolemma
cellular component assembly involved in morphogenesis
nuclear matrix
cornification
actomyosin structure organization
intermediate filament
tumor necrosis factor-mediated signaling pathway
Z disc
striated muscle cell development
muscle cell development
placenta development
cell-cell junction
striated muscle cell differentiation
keratinization
cellular response to tumor necrosis factor
muscle cell differentiation
response to tumor necrosis factor
protein-containing complex binding
keratinocyte differentiation
apoptotic signaling pathway
epidermal cell differentiation
response to acid chemical
in utero embryonic development
skin development
epidermis development