KYNU [The Human Chemical-Genetic Interaction Map Project]

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======= KYNU =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KYNU
  * **<color #00a2e8>Official Name</color>**: kynureninase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8942|8942]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16719|Q16719]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KYNU&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KYNU|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605197|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aminotran 5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|kynureninase activity|
|response to vitamin B6|
|3-hydroxykynureninase activity|
|tryptophan catabolic process to acetyl-CoA|
|anthranilate metabolic process|
|L-kynurenine catabolic process|
|quinolinate biosynthetic process|
|tryptophan catabolic process to kynurenine|
|quinolinate metabolic process|
|de novo NAD biosynthetic process|
|de novo NAD biosynthetic process from tryptophan|
|L-kynurenine metabolic process|
|ketone catabolic process|
|indolalkylamine catabolic process|
|indole-containing compound catabolic process|
|tryptophan catabolic process|
|kynurenine metabolic process|
|tryptophan metabolic process|
|dicarboxylic acid biosynthetic process|
|indolalkylamine metabolic process|
|amine catabolic process|
|cellular biogenic amine catabolic process|
|indole-containing compound metabolic process|
|benzene-containing compound metabolic process|
|aromatic amino acid family catabolic process|
|NAD biosynthetic process|
|acetyl-CoA metabolic process|
|pyridine nucleotide biosynthetic process|
|nicotinamide nucleotide biosynthetic process|
|pyridine nucleotide metabolic process|
|nicotinamide nucleotide metabolic process|
|pyridine-containing compound biosynthetic process|
|aromatic amino acid family metabolic process|
|pyridine-containing compound metabolic process|
|oxidoreduction coenzyme metabolic process|
|pyridoxal phosphate binding|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|amine metabolic process|
|cellular ketone metabolic process|
|response to vitamin|
|water-soluble vitamin metabolic process|
|acyl-CoA metabolic process|
|thioester metabolic process|
|dicarboxylic acid metabolic process|
|alpha-amino acid catabolic process|
|vitamin metabolic process|
|cellular amino acid catabolic process|
|ribonucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|coenzyme biosynthetic process|
|response to interferon-gamma|
|alpha-amino acid metabolic process|
|cofactor biosynthetic process|
|response to nutrient|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|aging|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|cofactor metabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic cyclic compound catabolic process|
|response to nutrient levels|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|innate immune response|
|cellular amide metabolic process|
|protein homodimerization activity|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|defense response to other organism|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13522
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KYNU Expression in NALM6 Cells: 5.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>