KYNU

Entrez Summary: Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010].
UniProt Summary: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

kynureninase activity
response to vitamin B6
3-hydroxykynureninase activity
tryptophan catabolic process to acetyl-CoA
anthranilate metabolic process
L-kynurenine catabolic process
quinolinate biosynthetic process
tryptophan catabolic process to kynurenine
quinolinate metabolic process
de novo NAD biosynthetic process
de novo NAD biosynthetic process from tryptophan
L-kynurenine metabolic process
ketone catabolic process
indolalkylamine catabolic process
indole-containing compound catabolic process
tryptophan catabolic process
kynurenine metabolic process
tryptophan metabolic process
dicarboxylic acid biosynthetic process
indolalkylamine metabolic process
amine catabolic process
cellular biogenic amine catabolic process
indole-containing compound metabolic process
benzene-containing compound metabolic process
aromatic amino acid family catabolic process
NAD biosynthetic process
acetyl-CoA metabolic process
pyridine nucleotide biosynthetic process
nicotinamide nucleotide biosynthetic process
pyridine nucleotide metabolic process
nicotinamide nucleotide metabolic process
pyridine-containing compound biosynthetic process
aromatic amino acid family metabolic process
pyridine-containing compound metabolic process
oxidoreduction coenzyme metabolic process
pyridoxal phosphate binding
cellular biogenic amine metabolic process
cellular amine metabolic process
amine metabolic process
cellular ketone metabolic process