L2HGDH

Gene Information
  • Official Symbol: L2HGDH
  • Official Name: L-2-hydroxyglutarate dehydrogenase
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 79944
  • UniProt: Q9H9P8
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: This gene encodes L-2-hydroxyglutarate dehydrogenase, a FAD-dependent enzyme that oxidizes L-2-hydroxyglutarate to alpha-ketoglutarate in a variety of mammalian tissues. Mutations in this gene cause L-2-hydroxyglutaric aciduria, a rare autosomal recessive neurometabolic disorder resulting in moderate to severe cognitive disability. [provided by RefSeq, Jul 2008].
  • UniProt Summary: N/A

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 3335
  • Expression level (log2 read counts): 5.62

Expression Distribution

  • Last modified: 2026/01/07 22:36
  • by 127.0.0.1