LAMP1 [The Human Chemical-Genetic Interaction Map Project]

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======= LAMP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LAMP1
  * **<color #00a2e8>Official Name</color>**: lysosomal associated membrane protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3916|3916]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11279|P11279]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LAMP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LAMP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/153330|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lamp|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phagolysosome membrane|
|positive regulation of natural killer cell degranulation|
|regulation of natural killer cell degranulation|
|alveolar lamellar body|
|cytolytic granule|
|granzyme-mediated apoptotic signaling pathway|
|autophagic cell death|
|Golgi to lysosome transport|
|autolysosome|
|regulation of organelle transport along microtubule|
|Golgi to vacuole transport|
|positive regulation of natural killer cell activation|
|positive regulation of leukocyte degranulation|
|positive regulation of natural killer cell mediated cytotoxicity|
|regulation of microtubule-based movement|
|positive regulation of natural killer cell mediated immunity|
|regulation of natural killer cell activation|
|multivesicular body|
|integral component of synaptic vesicle membrane|
|regulation of natural killer cell mediated cytotoxicity|
|regulation of natural killer cell mediated immunity|
|regulation of leukocyte degranulation|
|positive regulation of regulated secretory pathway|
|positive regulation of leukocyte mediated cytotoxicity|
|azurophil granule membrane|
|ficolin-1-rich granule membrane|
|positive regulation of cell killing|
|virus receptor activity|
|regulation of leukocyte mediated cytotoxicity|
|positive regulation of exocytosis|
|viral entry into host cell|
|sarcolemma|
|regulation of cell killing|
|melanosome|
|post-Golgi vesicle-mediated transport|
|entry into host cell|
|entry into host|
|positive regulation of lymphocyte mediated immunity|
|lysosomal transport|
|late endosome membrane|
|late endosome|
|positive regulation of leukocyte mediated immunity|
|vacuolar transport|
|cytosolic transport|
|regulation of lymphocyte mediated immunity|
|interaction with host|
|regulation of regulated secretory pathway|
|protein stabilization|
|viral life cycle|
|regulation of leukocyte mediated immunity|
|endosome membrane|
|positive regulation of immune effector process|
|regulation of microtubule-based process|
|regulation of exocytosis|
|protein domain specific binding|
|lysosome|
|apoptotic signaling pathway|
|regulation of protein stability|
|lysosomal membrane|
|positive regulation of innate immune response|
|enzyme binding|
|regulation of intracellular transport|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|neuronal cell body|
|Golgi vesicle transport|
|external side of plasma membrane|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|dendrite|
|establishment of protein localization to organelle|
|positive regulation of secretion|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of response to biotic stimulus|
|regulation of vesicle-mediated transport|
|myeloid leukocyte activation|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|perinuclear region of cytoplasm|
|viral process|
|regulated exocytosis|
|protein localization to organelle|
|regulation of secretion by cell|
|regulation of defense response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|symbiotic process|
|exocytosis|
|regulation of secretion|
|interspecies interaction between organisms|
|positive regulation of immune response|
|regulation of cellular localization|
|apoptotic process|
|leukocyte activation|
|positive regulation of transport|
|regulation of cellular component movement|
|secretion by cell|
|export from cell|
|programmed cell death|
|cell activation|
|immune effector process|
|cell death|
|regulation of response to external stimulus|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|integral component of plasma membrane|
|regulation of response to stress|
|intracellular transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of immune system process|
|establishment of localization in cell|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.77|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9638
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LAMP1 Expression in NALM6 Cells: 7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>