LAMP1
Gene Information
- Official Symbol: LAMP1
- Official Name: lysosomal associated membrane protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3916
- UniProt: P11279
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.
Pfam Domains GO Terms
Pfam Domains
| Lamp |
GO Terms
| phagolysosome membrane |
| positive regulation of natural killer cell degranulation |
| regulation of natural killer cell degranulation |
| alveolar lamellar body |
| cytolytic granule |
| granzyme-mediated apoptotic signaling pathway |
| autophagic cell death |
| Golgi to lysosome transport |
| autolysosome |
| regulation of organelle transport along microtubule |
| Golgi to vacuole transport |
| positive regulation of natural killer cell activation |
| positive regulation of leukocyte degranulation |
| positive regulation of natural killer cell mediated cytotoxicity |
| regulation of microtubule-based movement |
| positive regulation of natural killer cell mediated immunity |
| regulation of natural killer cell activation |
| multivesicular body |
| integral component of synaptic vesicle membrane |
| regulation of natural killer cell mediated cytotoxicity |
| regulation of natural killer cell mediated immunity |
| regulation of leukocyte degranulation |
| positive regulation of regulated secretory pathway |
| positive regulation of leukocyte mediated cytotoxicity |
| azurophil granule membrane |
| ficolin-1-rich granule membrane |
| positive regulation of cell killing |
| virus receptor activity |
| regulation of leukocyte mediated cytotoxicity |
| positive regulation of exocytosis |
| viral entry into host cell |
| sarcolemma |
| regulation of cell killing |
| melanosome |
| post-Golgi vesicle-mediated transport |
| entry into host cell |
| entry into host |
| positive regulation of lymphocyte mediated immunity |
| lysosomal transport |
| late endosome membrane |
| late endosome |
| positive regulation of leukocyte mediated immunity |
| vacuolar transport |
| cytosolic transport |
| regulation of lymphocyte mediated immunity |
| interaction with host |
| regulation of regulated secretory pathway |
| protein stabilization |
| viral life cycle |
| regulation of leukocyte mediated immunity |
| endosome membrane |
| positive regulation of immune effector process |
| regulation of microtubule-based process |
| regulation of exocytosis |
| protein domain specific binding |
| lysosome |
| apoptotic signaling pathway |
| regulation of protein stability |
| lysosomal membrane |
| positive regulation of innate immune response |
| enzyme binding |
| regulation of intracellular transport |
| positive regulation of lymphocyte activation |
| positive regulation of response to biotic stimulus |
| neuronal cell body |
| Golgi vesicle transport |
| external side of plasma membrane |
| positive regulation of secretion by cell |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| dendrite |
| establishment of protein localization to organelle |
| positive regulation of secretion |
| regulation of innate immune response |
| regulation of immune effector process |
| positive regulation of defense response |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| positive regulation of multi-organism process |
| leukocyte degranulation |
| regulation of lymphocyte activation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| regulation of response to biotic stimulus |
| regulation of vesicle-mediated transport |
| myeloid leukocyte activation |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of cell activation |
| perinuclear region of cytoplasm |
| viral process |
| regulated exocytosis |
| protein localization to organelle |
| regulation of secretion by cell |
| regulation of defense response |
| leukocyte mediated immunity |
| regulation of multi-organism process |
| symbiotic process |
| exocytosis |
| regulation of secretion |
| interspecies interaction between organisms |
| positive regulation of immune response |
| regulation of cellular localization |
| apoptotic process |
| leukocyte activation |
| positive regulation of transport |
| regulation of cellular component movement |
| secretion by cell |
| export from cell |
| programmed cell death |
| cell activation |
| immune effector process |
| cell death |
| regulation of response to external stimulus |
| secretion |
| regulation of immune response |
| positive regulation of immune system process |
| integral component of plasma membrane |
| regulation of response to stress |
| intracellular transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of immune system process |
| establishment of localization in cell |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Salinomycin 3.5μM R08 exp521 | -1.77 |
| Pterostilbene 16μM R02 exp78 | 1.78 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9638
- Expression level (log2 read counts): 7.68
Expression Distribution
LAMP1 Expression in NALM6 Cells: 7.68
