LANCL2 [The Human Chemical-Genetic Interaction Map Project]

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======= LANCL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LANCL2
  * **<color #00a2e8>Official Name</color>**: LanC like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55915|55915]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NS86|Q9NS86]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LANCL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LANCL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612919|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. {ECO:0000269|PubMed:19667068}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LANC like|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of response to alcohol|
|positive regulation of abscisic acid-activated signaling pathway|
|positive regulation of response to alcohol|
|regulation of abscisic acid-activated signaling pathway|
|positive regulation of cellular response to alcohol|
|regulation of cellular response to alcohol|
|phosphatidylinositol-5-phosphate binding|
|phosphatidylinositol-4-phosphate binding|
|phosphatidylinositol-3-phosphate binding|
|catalytic activity|
|cortical actin cytoskeleton|
|GTP binding|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|positive regulation of signal transduction|
|negative regulation of gene expression|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-2.18|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.82|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-1.74|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.74|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|1.75|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.75|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.76|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.92|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.99|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|2.02|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|2.3|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.31|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.41|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.76|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4548
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LANCL2 Expression in NALM6 Cells: 4.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>