LANCL2

Entrez Summary: N/A
UniProt Summary: Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. {ECO:0000269|PubMed:19667068}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of response to alcohol
positive regulation of abscisic acid-activated signaling pathway
positive regulation of response to alcohol
regulation of abscisic acid-activated signaling pathway
positive regulation of cellular response to alcohol
regulation of cellular response to alcohol
phosphatidylinositol-5-phosphate binding
phosphatidylinositol-4-phosphate binding
phosphatidylinositol-3-phosphate binding
catalytic activity
cortical actin cytoskeleton
GTP binding
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
ATP binding
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
positive regulation of signal transduction
negative regulation of gene expression
positive regulation of cell communication
positive regulation of signaling