LARP6

Entrez Summary: N/A
UniProt Summary: Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. {ECO:0000269|PubMed:20603131, ECO:0000269|PubMed:21746880, ECO:0000269|PubMed:22190748}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rapamycin 10μM R00 exp30	-1.9
39°C R06 exp303	-1.72

SUZ-C
La

positive regulation of mRNA binding
positive regulation of RNA binding
regulation of mRNA binding
sequence-specific mRNA binding
regulation of RNA binding
RNA stem-loop binding
myosin binding
mRNA 5-UTR binding
positive regulation of collagen biosynthetic process
positive regulation of collagen metabolic process
regulation of collagen biosynthetic process
regulation of collagen metabolic process
polysome
positive regulation of translation
positive regulation of cellular amide metabolic process
ribonucleoprotein complex
positive regulation of binding
regulation of translation
regulation of binding
regulation of cellular amide metabolic process
posttranscriptional regulation of gene expression
RNA processing
positive regulation of cellular protein metabolic process
RNA metabolic process
positive regulation of protein metabolic process
positive regulation of molecular function
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
gene expression
positive regulation of biosynthetic process