LARS [The Human Chemical-Genetic Interaction Map Project]

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======= LARS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LARS1
  * **<color #00a2e8>Official Name</color>**: leucyl-tRNA synthetase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51520|51520]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P2J5|Q9P2J5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LARS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LARS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/151350|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs. {ECO:0000269|PubMed:19426743}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA-synt 1e|
|tRNA-synt 1g|
|Anticodon 1|
|tRNA-synt 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|leucine-tRNA ligase activity|
|glutaminyl-tRNA aminoacylation|
|glutamine-tRNA ligase activity|
|leucyl-tRNA aminoacylation|
|cellular response to leucine|
|cellular response to leucine starvation|
|aminoacyl-tRNA synthetase multienzyme complex|
|response to leucine|
|aminoacyl-tRNA metabolism involved in translational fidelity|
|aminoacyl-tRNA editing activity|
|positive regulation of TORC1 signaling|
|protein targeting to lysosome|
|regulation of translational fidelity|
|protein targeting to vacuole|
|protein localization to lysosome|
|regulation of TORC1 signaling|
|positive regulation of TOR signaling|
|cellular response to amino acid starvation|
|tRNA aminoacylation for protein translation|
|response to amino acid starvation|
|establishment of protein localization to vacuole|
|tRNA aminoacylation|
|amino acid activation|
|protein localization to vacuole|
|cellular response to amino acid stimulus|
|endomembrane system|
|negative regulation of autophagy|
|regulation of TOR signaling|
|lysosomal transport|
|response to amino acid|
|vacuolar transport|
|cellular response to starvation|
|regulation of cell size|
|tRNA metabolic process|
|response to starvation|
|cellular response to acid chemical|
|cellular response to nutrient levels|
|lysosome|
|negative regulation of cellular catabolic process|
|cellular response to extracellular stimulus|
|GTPase activator activity|
|nuclear body|
|negative regulation of catabolic process|
|cellular amino acid metabolic process|
|regulation of autophagy|
|cellular response to external stimulus|
|response to acid chemical|
|protein targeting|
|regulation of cellular component size|
|translation|
|peptide biosynthetic process|
|positive regulation of GTPase activity|
|establishment of protein localization to organelle|
|ncRNA metabolic process|
|regulation of GTPase activity|
|response to nutrient levels|
|regulation of anatomical structure size|
|amide biosynthetic process|
|peptide metabolic process|
|response to extracellular stimulus|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|protein localization to organelle|
|positive regulation of hydrolase activity|
|cellular amide metabolic process|
|regulation of cellular catabolic process|
|carboxylic acid metabolic process|
|regulation of catabolic process|
|intracellular protein transport|
|response to organonitrogen compound|
|oxoacid metabolic process|
|endoplasmic reticulum|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-2.65|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.33|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.85|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.82|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.81|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.82|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|1.87|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.89|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|2.36|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|2.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.442|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 171/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|8/28|
|bone|8/26|
|breast|6/33|
|central nervous system|9/56|
|cervix|1/4|
|colorectal|7/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|4/21|
|liver|4/20|
|lung|19/75|
|lymphocyte|5/16|
|ovary|7/26|
|pancreas|4/24|
|peripheral nervous system|2/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|8/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|5/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 74
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LARS Expression in NALM6 Cells: 7.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>