LAS1L [The Human Chemical-Genetic Interaction Map Project]

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======= LAS1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LAS1L
  * **<color #00a2e8>Official Name</color>**: LAS1 like ribosome biogenesis factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81887|81887]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y4W2|Q9Y4W2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LAS1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LAS1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300964|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22872859}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Las1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Las1 complex|
|maturation of LSU-rRNA|
|preribosome, large subunit precursor|
|maturation of 5.8S rRNA|
|MLL1 complex|
|endonuclease activity|
|ribosomal large subunit biogenesis|
|rRNA processing|
|rRNA metabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-2.33|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.19|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-2.1|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-2.07|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.02|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.98|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.98|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.96|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.92|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-1.89|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.89|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.83|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.83|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.83|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.81|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.78|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.75|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.7|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|1.71|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.02|
|[[:results:exp224|CB-839 10μM R05 exp224]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 259/683
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|13/28|
|blood|8/26|
|bone|9/25|
|breast|10/30|
|central nervous system|19/49|
|cervix|1/4|
|colorectal|7/17|
|esophagus|7/11|
|fibroblast|0/1|
|gastric|3/14|
|kidney|6/18|
|liver|5/19|
|lung|31/72|
|lymphocyte|5/14|
|ovary|8/25|
|pancreas|11/22|
|peripheral nervous system|7/15|
|plasma cell|3/12|
|prostate|0/1|
|skin|8/20|
|soft tissue|4/7|
|thyroid|1/2|
|upper aerodigestive|12/22|
|urinary tract|12/28|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 140
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LAS1L Expression in NALM6 Cells: 6.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>