LAS1L

Entrez Summary: N/A
UniProt Summary: Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22872859}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 259/683

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	13/28
blood	8/26
bone	9/25
breast	10/30
central nervous system	19/49
cervix	1/4
colorectal	7/17
esophagus	7/11
fibroblast	0/1
gastric	3/14
kidney	6/18
liver	5/19
lung	31/72
lymphocyte	5/14
ovary	8/25
pancreas	11/22
peripheral nervous system	7/15
plasma cell	3/12
prostate	0/1
skin	8/20
soft tissue	4/7
thyroid	1/2
upper aerodigestive	12/22
urinary tract	12/28
uterus	1/5

Expression Distribution

Las1 complex
maturation of LSU-rRNA
preribosome, large subunit precursor
maturation of 5.8S rRNA
MLL1 complex
endonuclease activity
ribosomal large subunit biogenesis
rRNA processing
rRNA metabolic process
nucleic acid phosphodiester bond hydrolysis
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
RNA binding
RNA metabolic process
membrane
gene expression