LAX1
Gene Information
- Official Symbol: LAX1
- Official Name: lymphocyte transmembrane adaptor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 54900
- UniProt: Q8IWV1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells. {ECO:0000269|PubMed:12359715}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| immunoglobulin secretion |
| inactivation of MAPK activity |
| SH2 domain binding |
| negative regulation of MAP kinase activity |
| negative regulation of T cell activation |
| negative regulation of leukocyte cell-cell adhesion |
| negative regulation of protein serine/threonine kinase activity |
| negative regulation of lymphocyte activation |
| B cell activation |
| immunoglobulin production |
| protein secretion |
| establishment of protein localization to extracellular region |
| protein localization to extracellular region |
| negative regulation of MAPK cascade |
| peptide secretion |
| negative regulation of leukocyte activation |
| negative regulation of cell-cell adhesion |
| production of molecular mediator of immune response |
| negative regulation of cell activation |
| membrane raft |
| negative regulation of protein kinase activity |
| negative regulation of kinase activity |
| negative regulation of cell adhesion |
| negative regulation of transferase activity |
| antigen receptor-mediated signaling pathway |
| regulation of leukocyte cell-cell adhesion |
| regulation of T cell activation |
| regulation of MAP kinase activity |
| lymphocyte activation |
| regulation of cell-cell adhesion |
| negative regulation of protein phosphorylation |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| immune response-activating cell surface receptor signaling pathway |
| protein kinase binding |
| immune response-regulating cell surface receptor signaling pathway |
| negative regulation of intracellular signal transduction |
| regulation of lymphocyte activation |
| regulation of protein serine/threonine kinase activity |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| immune response-activating signal transduction |
| negative regulation of protein modification process |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| adaptive immune response |
| activation of immune response |
| regulation of cell activation |
| regulation of cell adhesion |
| regulation of MAPK cascade |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| positive regulation of immune response |
| regulation of kinase activity |
| leukocyte activation |
| regulation of transferase activity |
| Golgi apparatus |
| secretion by cell |
| negative regulation of cellular protein metabolic process |
| export from cell |
| cell activation |
| negative regulation of protein metabolic process |
| secretion |
| negative regulation of molecular function |
| regulation of immune response |
| positive regulation of immune system process |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| protein transport |
| peptide transport |
| amide transport |
| regulation of phosphorylation |
| establishment of protein localization |
| negative regulation of response to stimulus |
| regulation of immune system process |
| intracellular signal transduction |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| nitrogen compound transport |
| regulation of protein modification process |
| immune response |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Momordin-Ic 10μM R08 exp506 | 1.76 |
| Temozolomide 200μM R04 exp189 | 2.02 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16596
- Expression level (log2 read counts): 2.19
Expression Distribution
LAX1 Expression in NALM6 Cells: 2.19
