LBH
Gene Information
- Official Symbol: LBH
- Official Name: LBH regulator of WNT signaling pathway
- Aliases and Previous Symbols: N/A
- Entrez ID: 81606
- UniProt: Q53QV2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway. {ECO:0000269|PubMed:17390236}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| regulation of mammary stem cell proliferation |
| positive regulation of mammary stem cell proliferation |
| positive regulation of somatic stem cell division |
| regulation of somatic stem cell division |
| positive regulation of somatic stem cell population maintenance |
| regulation of somatic stem cell population maintenance |
| positive regulation of stem cell population maintenance |
| regulation of stem cell division |
| negative regulation of intracellular estrogen receptor signaling pathway |
| mammary gland epithelial cell differentiation |
| negative regulation of stem cell differentiation |
| regulation of stem cell population maintenance |
| negative regulation of intracellular steroid hormone receptor signaling pathway |
| regulation of intracellular estrogen receptor signaling pathway |
| mammary gland epithelium development |
| regulation of intracellular steroid hormone receptor signaling pathway |
| positive regulation of cell division |
| regulation of stem cell differentiation |
| mammary gland development |
| regulation of cell division |
| gland development |
| protein-containing complex |
| epithelial cell differentiation |
| negative regulation of cell differentiation |
| regulation of MAPK cascade |
| positive regulation of cell population proliferation |
| negative regulation of developmental process |
| epithelium development |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Q15 2.7μM R02 exp79 | 1.74 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12217
- Expression level (log2 read counts): 4.51
Expression Distribution
LBH Expression in NALM6 Cells: 4.51
