LBX1

Entrez Summary: This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles. [provided by RefSeq, Jul 2008].
UniProt Summary: Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

spinal cord association neuron specification
regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification
neuron fate determination
spinal cord association neuron differentiation
regulation of transcription involved in cell fate commitment
dorsal spinal cord development
neuron fate specification
spinal cord motor neuron differentiation
cell fate determination
ventral spinal cord development
cell differentiation in spinal cord
heart looping
neuron fate commitment
embryonic heart tube morphogenesis
determination of heart left/right asymmetry
embryonic heart tube development
cell fate specification
spinal cord development
determination of left/right symmetry
determination of bilateral symmetry
specification of symmetry
central nervous system neuron differentiation
transcription factor complex
negative regulation of neuron differentiation
cell fate commitment
heart morphogenesis
embryonic organ morphogenesis
negative regulation of neurogenesis
muscle organ development
epithelial tube morphogenesis
negative regulation of nervous system development
negative regulation of cell development
sequence-specific DNA binding
morphogenesis of an epithelium
embryonic organ development
pattern specification process
muscle structure development
heart development
tissue morphogenesis
embryonic morphogenesis