LCA5

Entrez Summary: This gene encodes a protein that is thought to be involved in centrosomal or ciliary functions. Mutations in this gene cause Leber congenital amaurosis type V. Alternatively spliced transcript variants are described. [provided by RefSeq, Oct 2009].
UniProt Summary: Might be involved in minus end-directed microtubule transport.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

photoreceptor cell maintenance
photoreceptor connecting cilium
intraciliary transport
protein transport along microtubule
microtubule-based protein transport
retina homeostasis
axoneme
ciliary basal body
transport along microtubule
cytoskeleton-dependent intracellular transport
microtubule-based transport
tissue homeostasis
cilium
protein-containing complex localization
protein-containing complex binding
microtubule-based movement
multicellular organismal homeostasis
anatomical structure homeostasis
cilium organization
microtubule-based process
intracellular protein transport
plasma membrane bounded cell projection organization
cell projection organization
protein transport
intracellular transport
peptide transport
movement of cell or subcellular component
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
homeostatic process
establishment of localization in cell
nitrogen compound transport