LCN1

Entrez Summary: N/A
UniProt Summary: Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

chloride ion binding
small molecule binding
cysteine-type endopeptidase inhibitor activity
long-chain fatty acid transport
sensory perception of taste
fatty acid transport
retina homeostasis
monocarboxylic acid transport
tissue homeostasis
negative regulation of endopeptidase activity
negative regulation of peptidase activity
carboxylic acid transport
organic acid transport
lipid transport
lipid localization
multicellular organismal homeostasis
signaling receptor binding
anatomical structure homeostasis
negative regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
organic anion transport
sensory perception of chemical stimulus
anion transport
regulation of proteolysis
negative regulation of catalytic activity
zinc ion binding
sensory perception
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
proteolysis
regulation of hydrolase activity
ion transport
nervous system process
extracellular space
homeostatic process
extracellular region
system process