LDB2

Entrez Summary: N/A
UniProt Summary: Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Adefovir 20μM R07 exp332	1.77
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	1.99
DABN 20μM R00 exp17	2.24

LIM domain binding
epithelial structure maintenance
cell leading edge
RNA polymerase II activating transcription factor binding
somatic stem cell population maintenance
hair follicle development
skin epidermis development
hair cycle process
molting cycle process
transcription coregulator activity
hair cycle
molting cycle
stem cell population maintenance
maintenance of cell number
tissue homeostasis
transcription factor complex
multicellular organismal homeostasis
anatomical structure homeostasis
enzyme binding
skin development
epidermis development
positive regulation of cellular component biogenesis
regulation of cell migration
nucleolus
negative regulation of transcription by RNA polymerase II
regulation of kinase activity
regulation of cell motility
regulation of cellular component biogenesis
regulation of transferase activity
regulation of locomotion
regulation of cellular component movement
epithelium development
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process