LDLRAD4

Gene Information

Official Symbol: LDLRAD4
Official Name: low density lipoprotein receptor class A domain containing 4
Aliases and Previous Symbols: N/A
Entrez ID: 753
UniProt: O15165
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8174
Expression level (log2 read counts): 7.32

Expression Distribution

negative regulation of SMAD protein complex assembly
regulation of SMAD protein complex assembly
negative regulation of pathway-restricted SMAD protein phosphorylation
R-SMAD binding
negative regulation of epithelial to mesenchymal transition
regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cellular response to transforming growth factor beta stimulus
regulation of epithelial to mesenchymal transition
regulation of transforming growth factor beta receptor signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of protein complex assembly
negative regulation of cellular response to growth factor stimulus
early endosome membrane
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of cell migration
regulation of cellular response to growth factor stimulus
negative regulation of cell motility
negative regulation of cellular component movement
negative regulation of locomotion
negative regulation of protein phosphorylation
negative regulation of phosphorylation
regulation of protein complex assembly
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
intracellular membrane-bounded organelle
negative regulation of cellular component organization
negative regulation of cell differentiation
regulation of cell migration
regulation of cell motility
negative regulation of developmental process
regulation of cellular component biogenesis
regulation of locomotion
regulation of cellular component movement
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of multicellular organismal process
negative regulation of signal transduction