LECT1 [The Human Chemical-Genetic Interaction Map Project]

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======= LECT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CNMD
  * **<color #00a2e8>Official Name</color>**: chondromodulin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11061|11061]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75829|O75829]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LECT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LECT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605147|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization. {ECO:0000269|PubMed:16980969}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BRICHOS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endothelial cell morphogenesis|
|negative regulation of vascular endothelial growth factor receptor signaling pathway|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|epithelial cell morphogenesis|
|negative regulation of endothelial cell proliferation|
|endothelial cell development|
|endomembrane system|
|endothelial cell differentiation|
|proteoglycan metabolic process|
|endothelium development|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|negative regulation of vasculature development|
|negative regulation of epithelial cell proliferation|
|regulation of endothelial cell proliferation|
|negative regulation of cellular response to growth factor stimulus|
|cartilage development|
|epithelial cell development|
|connective tissue development|
|regulation of cellular response to growth factor stimulus|
|regulation of angiogenesis|
|regulation of vasculature development|
|regulation of epithelial cell proliferation|
|glycoprotein metabolic process|
|skeletal system development|
|cell morphogenesis involved in differentiation|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|cell morphogenesis|
|cellular component morphogenesis|
|negative regulation of developmental process|
|carbohydrate derivative metabolic process|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cell development|
|tissue development|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.7|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5200
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LECT1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>